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在泛癌中RAB13表达的临床影响基于多个数据库的综合性分析

Xu-Dong Zhang¹, Zhong-Yuan Liu¹, Kai Luo¹

¹Departments of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China.

Scientific reports

|October 6, 2023

概括

大脑中的Ras相关 (RAB) 13是许多癌症的关键因素. 这项研究表明RAB13具有差异表达,并且与几种癌症的预后不佳有关,这表明它是潜在的治疗标.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

全球癌症发病率正在上升,对健康造成重大负担.
脑中的Ras相关 (RAB) 13已与各种瘤类型有关,但其精确的作用需要进一步调查.
了解RAB13在癌症中的机制对于开发向疗法至关重要.

研究的目的:

研究RAB13在人类胰腺癌中的功能.
探索RAB13在各种癌症类型中的差异表达,生存预后和免疫学作用.
预先调查肝细胞癌 (LIHC) 中RAB13的潜在机制.

主要方法:

利用TIMER2.0,GEPIA 2和UALCAN数据库进行差异表达,生存和病理阶段分析.
使用CBioPortal数据库分析突变水平,并通过STRING网站构建蛋白质-蛋白质相互作用 (PPI) 网络.
采用单个样本基因组丰富分析 (ssGSEA) 进行免疫透和基因组丰富分析 (GSEA) 进行LIHC的机理洞察.

主要成果:

在多种癌症中,RAB13表现出差异性表达,特别是肝细胞癌 (LIHC) 和胃腺癌 (STAD).
过度表达RAB13与LGG和LIHC的总生存率 (OS) 和无病生存率 (DFS) 更差相关.
在几种癌症的早期阶段,RAB13表达升高,其中"放大"是最常见的突变;它与免疫细胞 (B细胞,T细胞,巨细胞等) 有正相关. 和免疫检查点 (PD1,PDL1,CTLA4) 在LIHC.

结论:

RAB13是一种重要的泛癌基因,与特定癌症类型的改变表达和不良预后有关.
RAB13在免疫透中发挥作用,并且与LIHC中的免疫检查点有关,这表明它参与了免疫调节.
在LIHC中,RAB13涉及至关重要的细胞通路,包括MTORC1信号传递,MYC标,细胞循环,DNA修复和P53通路,将其定位为潜在的预后标记物和治疗标.

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