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潮湿气候对类风湿性关节炎便微生物群和代谢物的影响
Dingnan Wang1, Zhili Zheng1, Han Yu2
1Institute of Synopsis of Golden Chamber Department, School of Chinese Medicine College, Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China.
Scientific reports
|October 6, 2023
概括
高湿度会通过改变肠道细菌和代谢物,增加炎症和氧化应激来恶化类风湿性关节炎 (RA). 这项研究揭示了湿度.
科学领域:
- 风湿病学和环境健康
- 微生物组研究 微生物组研究
- 代谢学 代谢学 代谢学
背景情况:
- 高湿度与类风湿性关节炎 (RA) 症状恶化有关,但潜在的机制尚不清楚.
- 研究湿度在RA病变发生过程中的作用的实验性动物研究很少.
- 现有的研究缺乏对肠道微生物群和与RA湿度相关的代谢变化进行全面分析.
研究的目的:
- 为了研究高湿度对关节炎发育和进展在原诱导性关节炎 (CIA) 鼠标模型的影响.
- 分析高湿度对肠道微生物群和便代谢物的影响,无论是健康的老鼠还是关节炎的老鼠.
- 探索肠道微生物组变化,代谢变化和高湿度条件下的炎症反应之间的相关性.
主要方法:
- 使用了原诱导性关节炎 (CIA) 和健康的斯普拉格-道利 (SD) 老鼠.
- 对便样本进行了综合代谢学分析.
- 进行了用于便微生物群分析的16S rRNA测序.
主要成果:
- 高湿度加剧了CIA老鼠的关节炎,由软骨病变,较高的关节炎得分和增加的促炎细胞因子证明.
- 在高湿度下,在健康老鼠和CIA老鼠中观察到便微生物组合的显著变化,包括与炎症相关的细菌的增加.
- 便代谢学揭示了两种大鼠群体的代谢物水平和与炎症和氧化应激相关的生物功能的显著变化.
- 在高湿度条件下,在便微生物群和便代谢物之间发现了强烈的相关性.
结论:
- 高湿度是风湿性关节炎发病和发展的不利因素.
- 该机制涉及湿度诱导的炎症反应和氧化应激,可能由肠道微生物群和代谢物失调调节介导.
- 需要进一步的研究来阐明高湿度影响RA病变的确切途径.
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