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异形性炎症性肌肉病变的流行病学
Thomas Khoo1,2,3, James B Lilleker1,4, Bernard Yu-Hor Thong5
1Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Nature reviews. Rheumatology
|October 6, 2023
概括
异常性炎症性肌肉病变 (IIM) 是一种罕见的自身免疫性疾病,影响肌肉和器官. 它们的流行病学是复杂的,正在研究发病率,风险因素和潜在的流行病影响.
科学领域:
- 风湿病学和免疫学
- 罕见疾病的流行病学.
背景情况:
- 异形性炎症性肌肉病 (Idiopathic inflammatory myopathies,IIMs) 是一组多样化的自身免疫性疾病,影响骨肌肉和潜在的其他器官,如皮肤,关节,肺和心脏.
- 由于不断变化的分类标准和通过诊断编码识别病例的局限性,IIM的流行病学数据具有挑战性.
研究的目的:
- 审查当前对形性炎症性肌肉病变的流行病学的理解.
- 识别知识缺口和未来IIM流行病学研究领域.
主要方法:
- 对IIM流行病学现有文献的审查.
- 对发病率和流行率数据的分析.
- 讨论已知和潜在的风险因素.
主要成果:
- 估计的IIM发病率在每10万人年中从0.2到2不等;患病率在每10万人中为2到25.
- 已知的危险因素包括年龄,性别,遗传,感染,药物,恶性瘤和地理位置.
- 种族差异,特别是在土著人口中,以及COVID-19大流行对IIM发生率的影响需要进一步调查.
结论:
- 国际医学院的流行病学呈现出需要进一步研究的复杂性.
- 了解种族差异和COVID-19大流行等最近全球事件的影响对于推进IIM研究和患者护理至关重要.
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