含有益生菌发酵溶酸盐作为主要功能成分的乳液对增强皮肤屏障的影响:一项随机的自我控制研究
Hongchang Cui1, Congrui Feng1, Tao Zhang1
1Qingdao Vland Biotech Co., Ltd., 596-1 Jiushui East Road, Laoshan District, Qingdao, 266102, China.
Scientific reports
|October 6, 2023
概括
这项研究发现,含有发酵溶酸盐的VHProbi® Mix R乳液显著改善了皮肤屏障功能. 它减少了皮肤间的水分流失和发红,同时增加了敏感皮肤参与者的水分补充.
科学领域:
- 皮肤病学和化品科学
- 微生物学 微生物学
- 生物技术是生物技术.
背景情况:
- 对于可以局部改善皮肤屏障功能的化品成分的需求日益增加.
- 发酵成分越来越多地被认为是它们在护肤方面的潜在好处.
- 了解益生菌衍生化合物的特定机制对于开发有效的局部治疗至关重要.
研究的目的:
- 为了评估含有VHProbi® Mix R的乳液的有效性,VHProbi® Mix R是发酵溶酸盐的混合物,用于增强皮肤屏障功能.
- 评估特定益生菌菌株及其发酵溶解酸对皮肤健康的体外和体内影响.
- 确定乳液对关键皮肤屏障参数和主观敏感皮肤症状的影响.
主要方法:
- 在实验室中,使用DPPH试验和Caenorhabditis elegans模型评估Lacticaseibacillus rhamnosus VHProbi® E06和L. paracasei VHProbi® E12的抗氧化能力.
- 在实验室评估发酵溶解酸对HaCaT细胞增殖和对刺激物 (金黄色葡萄球菌,过氧化,UVB) 的保护的影响.
- 一项为期30天的临床研究,参与者使用VHProbi® Mix R乳液,使用VISIA®-CR和CK®-MPA系统测量皮肤间的水分流失 (TEWL),皮肤保湿和发红,以及敏感皮肤负担 (BoSS) 和自我评估问卷.
主要成果:
- 试验室研究证实了发酵溶解酸的抗氧化特性和保护作用,防止细胞损伤和刺激物质.
- 临床结果显示,在30天的乳液应用后,TEWL (P<0.01) 和红色 (P<0.01) 显著减少.
- 观察到皮肤保湿的显著改善,敏感皮肤负担 (BoSS) 评分和自我报告结果的积极变化.
结论:
- 局部应用VHProbi® Mix R显示了增强皮肤屏障功能的显著益处.
- 该乳液有效地减少了皮肤屏障受损的关键指标,并改善了敏感皮肤个体的整体皮肤状况.
- VHProbi® Mix R代表了一种有前途的功能化品成分,用于管理和改善敏感皮肤屏障健康.
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