慢性炎症不介导脂肪对握力的影响:来自多变量门德尔随机化研究的结果
Tom Norris1, Eleanor Sanderson2, Rachel Cooper3,4
1Division of Surgery and Interventional Science, Faculty of Medical Sciences, Institute of Sport, Exercise and Health, UCL, London, UK.
Scientific reports
|October 6, 2023
概括
肥胖可能会影响握力,但这种联系并不能通过炎症来解释. 影响因性别和脂肪分布而异,这表明身体组成和体力之间存在复杂的关系.
科学领域:
- 人体生理学 人体生理学
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 肥胖 (身体脂肪) 和握力 (GS) 有着复杂的关系.
- 慢性炎症是脂肪和GS之间的潜在调解者.
- 了解这些联系对于公共卫生和衰老研究至关重要.
研究的目的:
- 为了研究脂肪和握力之间的因果关系.
- 为了确定慢性炎症是否介导脂肪对握力的影响.
- 为了探索肥胖度与握力的性别特异关系.
主要方法:
- 利用了来自367,583名参与者的英国生物库数据.
- 采用单变量和多变量门德尔随机化 (MR) 分析.
- 评估了体重指数 (BMI),腰比 (WHR) 和C反应蛋白 (CRP) 的遗传仪器变量.
主要成果:
- 观察数据显示,更高的BMI与更强的握力有关,特别是在男性中.
- 核磁共振分析表明BMI和WHR对GS的性别特异性影响.
- C-反应蛋白 (CRP) 在调解脂肪对握力影响方面起到了微不足道的作用.
结论:
- 较大的脂肪可能会增强早期老年人的握力,影响因性别和脂肪分布而异.
- 没有显著的证据支持炎症作为肥胖-握力关系的调解者.
- 这些发现突出了身体组成,遗传学和身体功能之间的微妙相互作用.
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