怀孕期间母亲高血压与青春期早期大脑结构和行为问题相关联
Qing Ma1, Yutong Cui2,3, Xiaoyang Han1
1Department of Neurology, Huashan Hospital, Institute of Science and Technology for Brain-Inspired Intelligence, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200433, China.
European child & adolescent psychiatry
|October 6, 2023
概括
怀孕期间母亲的高血压与长期的行为问题和后代改变的大脑结构有关. 对于妊娠引起的高血压的早期干预对儿童发育至关重要.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 公共卫生 公共卫生
背景情况:
- 怀孕期间母亲的高血压越来越多地与后代的心理健康有关.
- 关于其对后代行为,大脑结构和发育轨迹的影响的理解有限.
研究的目的:
- 调查孕期孕产妇高血压对青少年早期行为和大脑解剖学的长期影响.
- 在两年时间内检查这些结果的发展变化.
主要方法:
- 利用了来自青少年大脑认知发展 (ABCD) 研究的11,878名参与者的神经成像和行为数据 (年龄为9-10岁和2年的随访).
- 包括在生育前的小鼠模型中的验证 (Nω-nitro-L-arginine甲基 - L-NAME).
主要成果:
- 患有高血压母亲的青少年在9-10岁和11-12岁时表现出更高的外部化和内部化行为得分.
- 这些参与者在9-10岁时表现出皮层厚度的增加,特别是在前端-平面-部区域.
- 四个大脑区域 (左侧副海马体,左侧轨道前叶,右上叶,右极) 在2年的随访中仍然更厚.
结论:
- 孕妇在怀孕期间的高血压可能会导致长期的行为问题和子女的大脑发育的改变.
- 临床医生和孕妇应该意识到这些风险;建议对妊娠引起的高血压进行干预.
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