一种混合堆叠-SMOTE模型,用于优化自闭症基因的预测
Eman Ismail1, Walaa Gad2, Mohamed Hashem2
1Information Systems Department, Faculty of Computer and Information Sciences, Ain Shams University, Cairo, Egypt. emanismail@cis.asu.edu.eg.
BMC bioinformatics
|October 6, 2023
概括
这项研究引入了一种新的Stack-SMOTE模型,可以准确预测自闭症谱系障碍 (ASD) 基因,达到95.5%的准确性. 该模型有效地处理不平衡的数据集,改善ASD的早期诊断.
科学领域:
- 遗传学和基因组学 遗传学和基因组学
- 计算生物学 计算生物学
- 神经科学是一个神经科学.
背景情况:
- 自闭症谱系障碍 (ASD) 是一种基于症状诊断的神经发育状况,原因是对致病基因的知识有限.
- 儿童早期诊断至关重要,但目前的方法缺乏遗传诊断信息.
- 识别引起疾病的基因对于改善ASD诊断至关重要.
研究的目的:
- 预测与自闭症谱系障碍 (ASD) 相关的综合基因组.
- 开发一个先进的计算模型,以提高ASD诊断.
- 解决遗传关联研究中数据集不平衡的挑战.
主要方法:
- 一个混合堆叠组合模型,Stack-SMOTE,是使用合成少数群体过量采样技术 (SMOTE) 开发的.
- 用混合基因相似性函数 (HGS) 来测量基因相似性,其中包括信息获取和基于图表的方法.
- 基于渐变增强的随机森林分类器 (GBBRF) 与其他分类器 (RF,k-NN,SVM,LR) 集成,以优化基因预测.
主要成果:
- 堆-SMOTE模型在现有的过量采样和不足采样技术中表现出优异的性能.
- 与个人基础分类器相比,GBBRF分类器实现了更高的准确性.
- 拟议的Stack-SMOTE模型在预测ASD相关基因方面达到约95.5%的准确性.
结论:
- 合成少数群体过量采样技术 (SMOTE) 有效地解决了自闭症遗传研究中的数据不平衡问题.
- 渐变增强和随机森林分类器 (GBBRF) 的整合创建了一个强大的堆叠组合模型 (Stack-SMOTE).
- 开发的模型显著提高了自闭症相关基因的预测准确度,有助于更好的诊断.
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