饮食摄入量和异常性肺纤维化发病率风险:孟德尔的随机化研究
Yilin Zhang1, Yihong Gan1, Hong Zhang2
1The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
BMC pulmonary medicine
|October 6, 2023
概括
油性鱼和干水果的饮食摄入量可以预防异常性肺纤维化 (IPF). 牛肉摄入量显示出潜在的联系,需要进一步调查饮食和肺部健康.
科学领域:
- 肺部病理学 肺部病理学
- 营养流行病学 营养流行病学
- 遗传流行病学遗传流行病学
背景情况:
- 饮食因素会影响癌症和喘等肺部疾病.
- 饮食在异常性肺纤维化 (IPF) 中的具体作用尚不清楚.
研究的目的:
- 调查饮食摄入量与异常性肺纤维化 (IPF) 之间的潜在因果关系.
- 使用两个样本的门德尔随机化 (MR) 方法来评估饮食对IPF风险的影响.
主要方法:
- 雇佣的英国生物库数据对饮食暴露 (肉类,水果,蔬菜,饮料) 和IPF病例 (451,025人) 的EBI数据库.
- 应用逆方差加权 (IVW),MR-Egger和加权中位数方法进行因果推断.
- 进行敏感性分析以验证发现并确保结果的可靠性.
主要成果:
- 油性鱼的摄入量表明对IPF有保护作用 (OR:0.995,P=6.458E-05).
- 干果摄入量也被确定为一种保护因素 (OR:0.995,P=0.001).
- 在牛肉摄入量和IPF风险之间观察到一种暗示性的积极关联 (OR: 1.006,P=0.023).
结论:
- 油性鱼和干水果的消费与IPF风险降低有关.
- 牛肉摄入量可能与IPF风险增加有关.
- 建议进行进一步的研究,以确认这些与IPF的饮食相关性.
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