抗抑郁药物用于预防第一发精神病后的抑郁症 (ADEPP):多中心,双盲,随机对照试验的研究方案
Edward R Palmer1,2,3, Siân Lowri Griffiths1, Ben Watkins4
1Institute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK.
Trials
|October 6, 2023
概括
这项研究调查了塞特拉林是否可以在患有第一发精神病 (FEP) 的人中预防抑郁症. 在ADEPP试验中,将评估塞特拉林.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 超过40%的第一发精神病 (FEP) 患者经历了抑郁症发作,结果恶化和医疗费用增加.
- 选择性血清素再吸收抑制剂,如塞特拉林,对抑郁症有效,与抗精神病药物安全.
- 以前的研究表明,塞特拉林在治疗精神分裂症抑郁症方面具有有效性.
研究的目的:
- 调查塞特拉林在预防FEP后抑郁症方面的疗效和成本效益.
- 评估塞特拉林在减少FEP患者抑郁症负担方面的潜力.
主要方法:
- 一个多中心,双盲,随机,安慰剂对照试验 (ADEPP) 涉及452名参与者 (18-65岁) 在FEP治疗开始后的12个月内.
- 参与者每天接受塞特拉林 (50毫克) 或安慰剂6个月,以及标准治疗.
- 主要结局:在6个月内出现新的抑郁病例. 二次结果:自杀行为,焦虑,复发率,功能结果,生活质量和资源使用.
主要成果:
- 关于新的抑郁症病例的初级结局数据将在塞特拉林和安慰剂组之间进行比较.
- 将分析关于自杀行为,焦虑,复发,功能,生活质量和资源使用的二次结果数据.
结论:
- 该ADEPP试验将确定是否将塞特拉林添加到FEP治疗中是临床有效的.
- 该研究将评估塞特拉林在FEP中改善结果的可接受性和成本效益.
- 这些发现将为早期精神病中抑郁症预防的治疗指南提供信息.
更多相关视频
相关概念视频
01:23Antidepressant Drugs: MAOIs and Other Agents
260
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
260
01:25Antidepressant Drugs: Overview
534
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
534
01:28Antidepressant Drugs: Tricyclics, SSRIs, and SNRIs
418
Tricyclic Antidepressants (TCAs), including Desipramine (Norpramin), Imipramine (Tofranil), Clomipramine (Anafranil), and Amitriptyline (Elavil), inhibit serotonin and norepinephrine reuptake and also block other receptors. They are used for depression, pain conditions, and insomnia. Common adverse effects include anticholinergic effects, sedation, orthostatic hypotension, and weight gain. They have a narrow therapeutic window and so require plasma-level monitoring. Abrupt discontinuation can...
418
01:28Psychosis and Antipsychotic Drugs: Overview
297
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
297
01:26Psychosis: Goals of Pharmacotherapy
150
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
150
01:24Mania and Antimanic Drugs: Overview
207
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
207