系统动态模拟用于评估基因组测序的实施策略:教程和概念模型.
Hadi A Khorshidi1,2,3, Deborah Marshall4, Ilias Goranitis5
1Cancer Health Services Research, University of Melbourne Centre for Cancer Research, Parkville, Australia.
Expert review of pharmacoeconomics & outcomes research
|October 7, 2023
概括
系统动力学 (SD) 为瘤学中的精准医学 (PM) 提供了强大的建模,简化了复杂的基因组测试和个性化治疗评估. 即使数据有限,SD在动态分析中也提供了优势,有助于战略决策.
科学领域:
- 卫生政策 卫生政策
- 计算生物学 计算生物学
- 在瘤学瘤学.
背景情况:
- 精准医学 (PM),特别是瘤学,依靠基因组特征进行复杂的诊断和治疗途径.
- 对PM的评估和决策需要先进的建模技术,因为其固有的复杂性.
- 系统动力学 (SD) 具有强大的建模能力,但在PM和个性化处理中未得到充分利用.
研究的目的:
- 在癌症背景下解释系统动力学 (SD) 工具.
- 建立在基因组测试和个性化瘤学中使用SD的理由.
- 开发一个概念模型,用于战略决策的全基因组测序 (WGS) 实施.
主要方法:
- 用癌症特定示例解释SD工具.
- 将SD与其他动态模拟建模 (DSM) 方法进行比较,强调SD的优势.
- 使用因果循环图 (CLD) 开发一个概念模型,用于WGS实施战略.
主要成果:
- SD适用于卫生政策评估和精确瘤学和基因组测试的建模.
- SD以系统为导向的方法利用反循环捕捉复杂的动态.
- SD模型是资源高效的,可以随着时间的推移进行探索性和解释性分析.
结论:
- SD为建模和评估复杂的卫生系统提供了显著的优势,特别是那些数据有限且需要可解释性的系统.
- SD能够建模动态交互和反循环的能力使得它对精确瘤学和基因组测试具有价值.
- 该概念模型展示了SD对实施全基因组测序等技术的战略决策的实用性.
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