食品乳化剂对高脂肪饮食引起的肥胖,肠道炎症,胆酸特征变化和肝功能障碍的影响
Wenwen Lv1, Jingyi Song1, Rifat Nowshin Raka1
1Beijing Technology and Business University, Beijing 100048, China; Beijing Engineering and Technology Research Center of Food Additives, Beijing 100048, China.
Food research international (Ottawa, Ont.)
|October 7, 2023
概括
食品乳化剂聚酸-80 (P80) 和聚糖醇聚烯酸 (PGPR) 并没有加剧肥胖,但增加了脂肪重量和炎症. 这些乳化剂改变了胆汁酸的形状,但没有改变小鼠的肠道微生物群组成.
科学领域:
- 营养科学 营养科学
- 胃肠病学 胃肠病学
- 毒理学 毒理学 毒理学
背景情况:
- 肥胖是一个主要的全球健康问题,通常与长期高脂肪饮食有关.
- 食品乳化剂,如多酸盐-80 (P80) 和多糖醇多酸 (PGPR) 在高脂肪食品中很常见.
- 它们对高脂肪饮食引起的肥胖和代谢障碍的影响尚未完全理解.
研究的目的:
- 研究P80和PGPR对脂质代谢,胆酸概况和肠道微生物群的影响.
- 评估它们对正常和高脂肪饮食诱导的小鼠肥胖模型的影响.
主要方法:
- 小鼠被养正常或高脂肪饮食,有或没有P80和PGPR.
- 评估的体重,能量摄入量,脂肪重量,血脂,结肠炎症和肝脏炎症因素.
- 分析了胆汁酸概况和肠道微生物群组成.
主要成果:
- P80和PGPR没有显著影响整体体重,但增加了 epididymal 脂肪重量和能量摄入量.
- 这两种乳化剂都提高了血脂水平,并诱导了结肠炎症,增加了结肠和肝脏的炎症因素.
- 虽然P80和PGPR改变了胆酸特征,但它们并没有改变肠道微生物群的组成.
结论:
- 通过增加脂肪积累和炎症,P80和PGPR可以对代谢健康产生负面影响,独立于肠道微生物群的改变.
- 研究结果表明,需要仔细考虑在食品中使用乳化剂.
- 这项研究为饮食指南和食品添加剂的合理应用提供了有价值的数据.
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