用CLNA丰富的石榴油功能化的酸奶的抗肥胖潜力
Manuela Machado1, Sérgio Sousa1, Luís M Rodriguez-Alcalá1
1Universidade Católica Portuguesa, CBQF Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.
Food research international (Ottawa, Ont.)
|October 7, 2023
概括
功能性酸奶与石榴油丰富,富含合烯酸 (CLNA),显示了对肥胖管理的希望. 这些酸奶改善营养状况,调节关键的代谢和免疫反应.
科学领域:
- 营养科学 营养科学
- 食品科学 食品科学 食品科学
- 生物化学 生物化学
背景情况:
- 石榴油含有联合烯酸 (CLNA),被认为具有潜在的肥胖管理应用.
- 克莱纳可以调节瘦素和阿迪波涅丁分泌,脂肪酸储存和葡萄糖代谢.
- 酸奶是一种潜在的食物矩阵,可以提供像CLNA这样的生物活性化合物.
研究的目的:
- 开发功能性酸奶,结合石榴油 (自由和封装) 以提高健康益处.
- 评估这些功能性酸奶对肝脏脂质积累,脂肪细胞代谢和免疫反应的影响.
- 评估CLNA丰富的酸奶在肥胖管理中的营养潜力.
主要方法:
- 石榴油 (自由和封装) 被纳入酸奶配方中.
- 评估了功能性酸奶对营养价值的影响,包括动脉增生和血栓增生指数.
- 实验室研究评估了酸奶在LPS刺激细胞中调节Hep G2细胞中的脂质积累,脂肪细胞代谢和炎症标记物 (IL-6,TNF-α) 的能力.
主要成果:
- 石榴油的添加显著改善了酸奶的营养特征,降低了动性 (>78%) 和血栓性 (>76%) 指数.
- 功能性酸奶减少了胆固醇诱导的Hep G2细胞中的40%,脂肪细胞中的30%.
- 酸奶调节了阿迪波金分泌,使阿迪波内克丁增加了56%,并减少了IL-6 (约44%) 和TNF-α (约12%).
结论:
- 富含石榴油的功能性酸奶提供了更好的营养质量,并具有有益于代谢健康的生物活性特性.
- 这些酸奶在调节脂质代谢,阿迪波金信号传递和炎症反应方面表现出潜在的潜力,这表明它在肥胖管理中的有效性.
- 富含CLNA的酸奶是治疗与肥胖有关的代谢功能障碍的一种有希望的营养替代品.
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