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Updated: Jul 14, 2025

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在接受干细胞移植的儿童中发作

Eulalia Turón-Viñas^1,2, Iván López-Torija³, Elisabet Coca-Fernández^1,2

¹Child Neurology Unit, Pediatrics Service, Hospital Sant Pau, Barcelona, Spain.

Pediatric transplantation

|October 7, 2023

概括

神经学并发症,特别是发作,是血液干细胞移植 (HSCT) 后的一个重大问题. 识别发作的风险因素和早期干预对于改善患者的治疗结果和生存率至关重要.

科学领域:

血液学血液学血液学
神经学神经学
儿科儿科儿科

背景情况:

血液干细胞移植 (HSCT) 后的神经并发症 (NCs) 是一个主要问题.
发作是接受HSCT的患者中常见的NCs表现.

研究的目的:

分析接受HSCT的儿童发作的发病率和病因.
确定与HSCT后发作相关的风险因素和结果.

主要方法:

在2002年至2018年间对155名接受HSCT的儿童进行了回顾性研究.
对发病率,原因,相关因素和结果的分析.

主要成果:

17.4%的儿童在HSCT后2年内发作.
常见的病因包括中枢神经系统感染,药物毒性和血管疾病.
发作与HSCT类型,特定药物和GVHD有关,并预测了包括死亡率和后果在内的不良结果.

结论:

神经学并发症,特别是发作,对HSCT患者的生存率和结果有显著的影响.
解决神经系统并发症对于改善HSCT程序和患者管理至关重要.

关键词:

孩子们的孩子们的孩子们的孩子们毒性毒性毒性毒性毒性毒性毒性毒性毒性毒性毒脑炎是一种脑炎.儿科中风儿科中风发作发作这些干细胞移植干细胞移植

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