维生素D代谢物比率与老年男性体积骨密度有关
Charles Ginsberg1, Terri Blackwell2, Jonathan H Cheng1,3
1Division of Nephrology-Hypertension, University of California, San Diego, CA 92037, USA.
The Journal of clinical endocrinology and metabolism
|October 7, 2023
概括
维生素D代谢物比率 (VMR) 与老年男性更好的骨密度和强度有关. 与25(OH) D不同,VMR可能是骨健康的更可靠指标.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 老年医学 老年医学
背景情况:
- 血清25-基维生素D (25(OH) D是维生素D状态的标准标志物,但其与骨健康结果的关联不一致.
- 维生素D代谢物比率 (VMR),计算为24,25-二氧维生素D3到25-OH) D3,已经显示出随着时间的推移跟踪骨矿物质密度 (BMD) 和骨折风险的潜力.
研究的目的:
- 研究VMR与骨健康之间的关系,特别是体积骨矿物质密度 (vBMD) 和骨强度.
- 用高分辨率的外围定量计算断层扫描 (HR-pQCT) 来比较VMR与骨健康指标的关联与25(OH) D的关联.
主要方法:
- 这项研究包括545名来自男性骨质疏松性骨折 (MrOS) 研究的老年男性.
- 使用HR-pQCT评估骨健康,以测量远半径和骨的vBMD和估计失效负载 (EFL).
- 使用统计模型来评估VMR和25(OH) D3与vBMD和EFL的关联.
主要成果:
- 在调整的分析中,更高的VMR与远距离半径和骨的vBMD和EFL增加显著相关.
- 每次VMR增加两倍都与9%更高的vBMD和13%更高的距离半径EFL相关.
- 血清25(OH) D3水平与测量的骨健康结果没有显著关联.
结论:
- 在老年男性中,VMR升高与改善体积骨矿物质密度和骨强度有关.
- 与25~OH) D相比,VMR可能是评估老年男性骨健康的更有效生物标志物.
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