二十四小时尿中氧酸盐和慢性病的风险
Marja Puurunen1, Caroline Kurtz1, Alistair Wheeler1
1Synlogic Therapeutics, Cambridge, MA, USA.
概括
24小时尿中酸盐 (UOx) 排泄率较高与患慢性病 (CKD) 的风险增加有关. 这种关联在各种UOx水平中观察到,并且在具有吸收不良条件的个体中更为明显.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 慢性病 (CKD) 是一个重要的全球健康问题.
- 了解可以修改的CKD风险因素对于预防至关重要.
- 氧沙酸代谢对脏健康起着重要作用.
研究的目的:
- 调查24小时尿中酸盐 (UOx) 排泄与CKD发病率之间的关联.
- 确定高氧化物水平是否是患CKD的独立风险因素.
主要方法:
- 一项纵向观察性研究,涉及426,896名没有基线CKD的美国成年人.
- 数据包括医疗保健索赔和电子医疗记录用于事件CKD识别.
- 后勤回归分析调整了多种混因素,包括人口统计,并发病症和尿液参数.
主要成果:
- 与24小时UOx分泌的较高类别 (≥20 mg/24 h) 相比,与<20 mg/24 h相比,观察到发生CKD的几率增加.
- 在所有研究的UOx类别中,这种关联在统计学上是显著的.
- 在吸收不良的个体中,与升高的UOx相关的CKD风险的大小显著更大.
结论:
- 在24小时内尿中氧酸盐分泌量的增加是发生CKD的重要危险因素.
- 这些发现表明,UOx水平可能作为CKD风险的生物标志物.
- 需要进一步的研究来探索减少UOx对CKD预防的潜在益处.
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