一个为期20年的人口对周边心肌病的研究
Alice M Jackson1, Mark Macartney2, Katriona Brooksbank1
1BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, 126 University Place, Glasgow G12 8TA, UK.
European heart journal
|October 7, 2023
概括
产前心肌病 (PPCM) 影响4950分之一的分娩,导致显著的母婴发病率和死亡率. 早期调查和长期跟踪对有风险的妇女至关重要.
科学领域:
- 心脏病学 心脏病学
- 产科 产科 产科 产科 产科
- 流行病学 流行病学
背景情况:
- 在欧洲,产前心肌病 (PPCM) 的流行病学和长期结果尚未得到充分证实.
- 苏格兰 (1998-2017年) 一项人口水平研究调查了PPCM病例.
- 确定并分析了PPCM的验证病例.
研究的目的:
- 确定苏格兰PPCM的发病率和风险因素.
- 检查受PPCM影响的母亲和儿童的长期发病率和死亡率.
- 提供关于PPCM的预后和管理的见解.
主要方法:
- 追溯性,观察性,人口水平的研究设计.
- 包括在怀孕期间住院患有新出现的左心室缩功能障碍的妇女.
- 将PPCM病例与10个对照进行匹配以进行比较.
主要成果:
- 在4950例分娩中,PPCM发生率为1例;相关因素包括肥胖和高血压疾病.
- 孕产妇死亡率为8%,75%被重新住院治疗;儿童面临更高的死亡率和心血管疾病风险.
- 左心室恢复发生在76%的女性中,但13%的女性经历了随后的衰退.
结论:
- PPCM影响4950例怀孕中的1例,造成严重的孕产妇和儿童健康负担.
- 建议对有风险的女性进行调查的门较低.
- 长期的随访是必不可少的,即使在明显康复后.
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