预测早期发病的局部晚期结肠癌的生存率和预后:一项回顾性观察性研究
Bangquan Chen1,2,3, Yue Ma2,3,4, Jiajie Zhou2,3,4
1Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225001, China.
International journal of colorectal disease
|October 7, 2023
概括
一个新的名图准确地预测了早期发病的局部晚期结肠癌 (LACC) 的癌症特异性生存率. 该工具帮助临床医生对LACC患者进行风险分层和个性化治疗决策.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 临床预后 临床预后
背景情况:
- 早期发病的局部晚期结肠癌 (LACC) 在预后方面提出了独特的挑战.
- 准确预测癌症特异性生存率 (CSS) 对于有效的治疗计划至关重要.
研究的目的:
- 开发和验证一种新型的名录模型,用于预测早期LACC患者的CSS.
- 建立一个风险分层系统来分类患者的风险水平.
主要方法:
- 从SEER数据库 (2010-2019) 中对LACC案件进行了回顾性分析.
- 早期发病 (≤50岁) 和晚期发病的结肠癌队列的比较.
- 多变量考克斯回归分析以确定显著的预后因素.
- 与AJCC-TNM系统相对应的诺莫格拉姆构建和验证.
主要成果:
- 该研究包括32,855名LACC患者;4,548名 (13.84%) 是早期发病.
- 早期发病的LACC显示出较差的预后指标,但与晚期发病相比,CSS更好.
- 开发的诺米图表在CSS预测方面比AJCC-TNM系统 (0.783比0.728培训;0.852比0.773验证) 显示出更高的准确性.
结论:
- 一种新型的名字图有效地预测了LACC早期发作的CSS.
- 诺姆图表作为一个有价值的工具,用于预后和个性化治疗选择.
- 该系统有助于临床医生为LACC管理做出明智的决定.
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