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诊断活检不能准确地反映PD-L1表达在三阴性乳腺癌的表达

Marek Zdrenka¹, Adam Kowalewski¹, Jędrzej Borowczak²

¹Department of Tumor Pathology and Pathomorphology, Oncology Center, Prof. Franciszek Łukaszczyk Memorial Hospital, Bydgoszcz ul. Romanowska, 85-796, Bydgoszcz, Poland.

Clinical and experimental medicine

|October 7, 2023

概括

活检样本可能不会准确地反映三阴性乳腺癌 (TNBC) 中的PD-L1表达. 这可能导致错误分类,可能会使患者从有益的免疫检查点抑制剂疗法中排除.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学

背景情况:

编程死亡配体1 (PD-L1) 表达是预测三阴性乳腺癌 (TNBC) 免疫检查点抑制剂 (ICI) 治疗反应的关键生物标志物.
对PD-L1表达的准确评估对于患者选择抗PD-L1治疗至关重要.

研究的目的:

调查活检样本中的PD-L1表达是否准确地代表了TNBC患者在整个瘤中的PD-L1表达.
为了确定诊断活检和相应的手术切除标本之间的PD-L1状态的差异.

主要方法:

免疫组织化学被用来评估PD-L1表达.
对81个活检和匹配的术后切除样本进行了分析,这些样本来自被诊断患有TNBC的患者.
在最初的活检样本和随后的手术样本中评估了PD-L1状态.

主要成果:

在28%的活检样本中检测到PD-L1阳性.
显著比例的最初PD-L1阴性活检样本 (31%) 在相应的切除样本中显示PD-L1阳性.
总体而言,在分析切除样本时,与活检相比,发现了22%更多的PD-L1阳性瘤,这是统计学上显著的差异 (p=0.0038).

结论:

诊断活检可能无法完全捕捉TNBC中PD-L1表达的异质性.
相当数量的TNBC患者可能被错误地归类为PD-L1阴性,可能无法获得有效的抗PD-L1疗法.

关键词:

癌症癌症癌症癌症诊断诊断诊断诊断是一个在PD-L1中.病理学病理学病理学三阴性乳腺癌是三阴性乳腺癌.

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