洞察D68肠道病毒的分子进化
1Clinical practice management office, Medical Manager at Hospital Moinhos de Vento, 333 Tiradentes Street, 13 floor, Porto Alegre, RS, 90560-030, Brazil. jonas.wolf@hmv.org.br.
Archives of virology
|October 7, 2023
概括
肠道病毒D68 (EV-D68) 是一种影响儿童的呼吸道病毒,起源于20世纪90年代的加拿大. 这项研究追踪了其全球传播和分子进化,跨越各种类.
科学领域:
- 病毒学 病毒学
- 分子进化分子进化
- 流行病学 流行病学
背景情况:
- 肠道病毒D68 (EV-D68) 是一种重要的呼吸道病原体,主要影响儿童.
- 在全球范围内,EV-D68已与呼吸系统疾病的零星爆发有关.
- 了解EV-D68的进化动态和地理传播对于公共卫生至关重要.
研究的目的:
- 为了研究D68.8肠道病毒的时间传播模式.
- 分析不同EV-D68细胞系 (A1,A2,B,B1,B2,B3和C) 的分子演变.
- 确定EV-D68.8的起源和全球传播途径.
主要方法:
- 贝叶斯的凝聚分析被用来重建病毒的进化历史.
- 从1977年到2022年收集的EV-D68的976个全基因组序列 (WGS) 的分析.
- 每个EV-D68类的最近共同祖先 (MRCA) 的约会.
主要成果:
- EV-D68的分子起源可以追溯到1995年的加拿大.
- 具体的分类有不同的起源和最近的共同祖先日期,其中包括A1 (美国,2005年),A2 (中国,2003年) 和B (中国,2003年).
- EV-D68已经在全球传播,在法国 (1997年),美国 (1999年),亚洲 (2008年) 有记录的引入,随后扩散到欧洲,大洋洲,拉丁美洲和非洲.
结论:
- 肠道病毒D68起源于20世纪90年代的加拿大.
- 病毒经历了显著的分子进化,导致了不同的分类的出现.
- EV-D68已经证明了其在全球范围内在各大洲传播的广泛能力.
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