焦虑和抑郁症状轨迹的模式和预测因素在被诊断为原发性脑瘤的患者中
Alayna E Ernster1, Anjelica Body2, Phuong Deleyrolle2
1Wake Forest University School of Medicine, Winston Salem, NC, USA.
Journal of neuro-oncology
|October 7, 2023
概括
主要脑瘤患者经常经历严重的焦虑和抑郁. 生活质量会影响这些心理健康症状,突出需要进行例行查和干预.
科学领域:
- 神经瘤学神经瘤学
- 心理社会瘤学
- 临床心理学 临床心理学
背景情况:
- 患有原发性脑瘤 (pPBTs) 的患者经常经历心理困扰.
- 了解焦虑和抑郁的发展轨迹对于管理pPBT患者的福祉至关重要.
- 识别症状变化的预测因素可以告知有针对性的干预措施.
研究的目的:
- 评估 pPBTs 的成年患者焦虑和抑郁症状随时间变化的情况.
- 为了确定预测个体患者症状轨迹的因素.
- 检查临床上升症状的患病率和这些症状的有意义的变化.
主要方法:
- 一项前性研究,涉及99名成年pPBT患者,持续6-18个月.
- 利用癌症治疗的功能性评估-大脑和患者报告的结果测量信息系统评估的简单表格.
- 采用线性混合效应模型和潜在类增长分析 (LCGA) 来分析症状变化.
主要成果:
- 在基线时,超过50%的患者患有高度焦虑,超过30%患有高度抑郁.
- 很大一部分患者 (50%以上) 经历了临床上有意义的焦虑和抑郁症的增加.
- 改善的身体,功能和脑癌福祉与较低的焦虑和抑郁水平相关.
结论:
- 高度焦虑和抑郁症在pPBT患者中很常见,并且可以显著波动.
- 常规查对于检测临床上有意义的症状变化至关重要.
- 确定症状变化的预后因素是有效的患者护理的关键.
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