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在过去二十年中,形甲状腺癌患者的结果的变化
Omar Abdel-Rahman1, Sunita Ghosh2
1Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, AB, Canada. omar.abdelsalam@ahs.ca.
Endocrine
|October 7, 2023
概括
近年来,无塑性甲状腺癌的生存率有所提高,在2017-2020年间诊断的患者的治疗结果更好. 需要进一步的研究,以提高所有患有这种侵袭性癌症的患者的生存率.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 甲状腺癌研究研究
背景情况:
- 无塑性甲状腺癌 (ATC) 是一种具有历史上不良预后的侵袭性内分泌恶性瘤.
- 了解生存结果的时间趋势对于评估治疗进展和公共卫生战略至关重要.
研究的目的:
- 为了评估在过去二十年中在美国被诊断患有形甲状腺癌的患者的整体存活率 (OS) 的变化.
- 确定影响ATC患者生存的因素.
主要方法:
- 对监测,流行病学和最终结果 (SEER) 数据库 (2004-2020) 的回顾性分析.
- 卡普兰-梅尔生存估计被用来比较三个诊断时期的OS:2004-2010,2011-2016年和2017-2020年.
- 多变量考克斯回归分析确定了OS的预测因素.
主要成果:
- 总共分析了1804名ATC患者.
- 与早期诊断队列相比,在2017-2020年间诊断的患者表现出显著改善的OS (P < 0.001).
- 一年生存率为25% (2017-2020年),15% (2011-2016年) 和19% (2004-2010年) 的情况. 早期诊断与更糟糕的生存率有关 (HR 1.170-1.251).
结论:
- 近年来,形甲状腺癌患者的生存结果呈现出积极的趋势.
- 尽管有所改善,但ATC仍然是一种高度致命的癌症,需要继续努力改善患者的治疗结果.
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