预测脑膜瘤外科切除后发作结果的因素:SOLID-C对预防性AED的指导方针
Guramritpal Singh1, Pawan Kumar Verma1, Arun Kumar Srivastava1
1Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India.
概括
识别诸如大脑入侵和包容体等因素可以预测经过脑膜瘤手术后的持续性发作. 这有助于定制抗药物预防,以改善患者的生活质量.
科学领域:
- 神经外科 神经外科
- 神经学 神经学
- 在瘤学瘤学.
背景情况:
- 在脑膜瘤患者中,发作很常见,影响生活质量.
- 手术切除是主要的治疗方法,但发作往往会在术后持续.
- 确定持续性发作的因素对于改善患者的治疗结果至关重要.
研究的目的:
- 分析预测脑膜瘤患者切割后发作结果的临床和组织病理因素.
- 确定预防性抗药物 (AED) 对脑膜瘤患者的必要性.
主要方法:
- 包括新诊断的脑膜瘤和手术前发作的成年患者.
- 该研究包括了在2007年至2020年期间接受初级瘤切除的患者.
- 需要至少12个月的随访期.
主要成果:
- 脑膜膜瘤入侵,手术前使用>2种抗药物和内核包容体独立地与不良的控制有关 (p < 0.001,p = 0.016,p = 0.001).
- 瘤大小,,位置,包容体,抗药物和手术并发症 (SOLID-C) 被确定为预防性AED的决定因素.
结论:
- 鉴定预测患控制的因素,可以指导脑膜瘤术后的治疗策略.
- 一项拟议的SOLID-C指南旨在个性化预防性AED使用,避免采取全面的方法.
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