相关实验视频

Updated: Aug 2, 2026

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor

Sensing of Barrier Tissue Disruption with an Organic Electrochemical Transistor

Published on: February 10, 2014

1,2-bis(2,4,6-tribromophenoxy) 乙是一种新型化阻燃剂,通过IRX3/NOS2轴在老鼠小肠中破坏肠道屏障功能

Yuan Cui¹, Qianqian Xiao¹, Zhenyu Wang¹

¹Department of Toxicology, School of Public Health, Peking University, Beijing 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, PR China.

Journal of hazardous materials

|October 7, 2023

概括

1,2-bis(2,4,6-tribromophenoxy) 乙 (BTBPE) 通过激活IRX3/NOS2轴引起肠损伤,导致亡和紧结的破坏. 阻止这种途径可以保护肠道细胞免受BTBPE毒性的影响.

科学领域:

毒理学毒理学毒理学
细胞生物学细胞生物学
胃肠病学胃肠病学

背景情况:

新型制阻燃剂,如1,2-bis(2,4,6-tribromophenoxy) 乙 (BTBPE) 是普遍存在的,但它们的肠道毒性机制尚不清楚.
尽管它在细胞过程中可能发挥作用,但对Iroquois homeobox 3 (IRX3) 功能的研究是有限的.

研究的目的:

在体内和体外研究BTBPE的肠道毒性机制.
探索IRX3/NOS2轴在BTBPE引起的肠损伤中的作用.
确定潜在的治疗目标,以减轻BTBPE毒性.

主要方法:

斯普拉格-道利大鼠和IEC6细胞暴露于BTBPE.
组织病理学分析 (HE,AB-PAS) 和分子分析 (qPCR,西式涂抹,免疫光).
对IRX3的基因沉默和NOS2的抑制,以评估它们的作用.

主要成果:

暴露于BTBPE引起了炎症,亡,紧密结节的破坏,以及膜和骨的粘液层的损失.
在肠道细胞中,BTBPE激活了IRX3/NOS2信号轴.
制IRX3或抑制NOS2改善了BTBPE诱导的亡,并恢复了紧结的完整性.

结论:

通过激活IRX3 / NOS2轴,BTBPE会导致肠道损伤,导致亡和紧密结节的破坏.
针对IRX3/NOS2通路提供了一个有希望的策略来抵消BTBPE引起的肠损伤.
这项研究阐明了IRX3/NOS2轴在亡和紧结调节中的新功能.

关键词:

BTBPE BTBPE 在线观看 IRX3 IRX3 的意思是肠道屏障肠道屏障肠道屏障在NOS2中,NOS2是NOS2.尸体灭 (Necroptosis) 是一种死亡的过程.紧密的结口紧密的结口.

更多相关视频

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

Rodent Model of Intestinal Ischemia-Reperfusion Injury via Occlusion of the Superior Mesenteric Artery

Rodent Model of Intestinal Ischemia-Reperfusion Injury via Occlusion of the Superior Mesenteric Artery

Published on: October 20, 2023

相关概念视频

Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene

Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene

Bromination and chlorination of aromatic rings by electrophilic aromatic substitution reactions are easily achieved, but fluorination and iodination are difficult to achieve. Fluorine is so reactive that its reaction with benzene is difficult to control, resulting in poor yields of monofluoroaromatic products. To address this, Selectfluor reagent is used as a fluorine source in which a fluorine atom is bonded to a positively charged nitrogen.