加拿大的一项病例控制研究调查了与MOGAD相关的人口和环境因素
Sam Hosseini-Moghaddam1, Ruth Ann Marrie2, Christina Wolfson3
1St. Michael's Hospital, Toronto, 30 Bond St., Toronto, Ontario M5B 1W8, Canada.
Multiple sclerosis and related disorders
|October 7, 2023
概括
肥胖和非白人族裔可能会增加患有髓寡基细胞蛋白抗体相关疾病 (MOGAD) 的风险. 成年人群中较高的BMI也与安大略省居民的MOGAD风险有关. 这些因素需要进一步调查.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 人口统计学和环境因素对髓寡腺细胞糖蛋白抗体相关疾病 (MOGAD) 基本上是未知的.
- MOGAD是一种自身免疫性脱髓化疾病,影响中枢神经系统.
研究的目的:
- 调查与MOGAD相关的人口和环境风险因素.
- 使用了病例控制设计和经过验证的多发性硬化症研究 (EnvIMS) 环境风险因素问卷.
主要方法:
- 在加拿大六个中心注册了39名MOGAD患者和956名对照.
- 使用EnvIMS问卷收集的数据.
- 采用后勤回归和Firth的方法来计算赔率比率.
主要成果:
- 10岁时体型较大 (OR: 3.57) 和非白人种族 (OR: 3.81) 与MOGAD概率增加有关.
- 在安大略省居民中,当前BMI≥30与更高的MOGAD几率 (OR:2.79) 有关.
结论:
- 研究结果表明,肥胖和种族是MOGAD的潜在风险因素.
- 需要进一步研究更大的样本大小来证实这些产生假设的结果.
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