变化的真菌感染流行病学
Cornelia Lass-Flörl1, Stephan Steixner1
1Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, A-6020, Innsbruck, Austria.
Molecular aspects of medicine
|October 7, 2023
概括
侵入性真菌病,包括候群病和阿斯伯吉洛症,在重症患者中正在增加. 新兴的真菌病原体对抗真菌药物产生耐药性,这一趋势在COVID-19大流行中加剧.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 侵袭性真菌病 (IFD) 是免疫力低下和重症患者的重大并发症.
- 真菌共同感染和超级感染是一个越来越令人担忧的问题,特别是候群病,阿斯伯吉洛症和粘菌菌病.
- 流行病学趋势表明,全球范围内这些IFD的发病率正在上升.
研究的目的:
- 突出IFD在脆弱患者群体中日益增长的患病率.
- 为了确定真菌病原体的新兴趋势,包括非白虫Candida和神秘的Aspergillus物种.
- 为了强调COVID-19大流行对IFD发病率的影响.
主要方法:
- 对欧洲和印度的IFD流行病学数据的审查.
- 分析致病性真菌物种的趋势,包括Candida和Aspergillus种群的变化.
- 评估COVID-19流行病对IFD发生的影响.
主要成果:
- 在欧洲, кандидоз和阿斯伯吉洛斯是主要的IFD,而在印度,粘膜菌是普遍存在的.
- 观察到这些真菌感染的发病率显著增加.
- 非白虫Candida和神秘的Aspergillus物种的出现,可能表现出抗真菌耐药性,正在增加.
- 由于COVID-19大流行,住院患者的IFD发病率显著增加.
结论:
- 国际防疫器具构成越来越大的威胁,特别是在免疫功能受损的个体和重症患者中.
- 随着真菌病原体的不断变化,需要对抗真菌耐药性保持警.
- 由于COVID-19大流行,IFD的负担增加了,需要紧急的临床和研究关注.
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