抗生素来自罕见的actinomycetes,超出了Streptomyces属的抗生素
Jonathan Parra1, Ainsley Beaton2, Ryan F Seipke3
1Instituto de Investigaciones Farmacéuticas (INIFAR), Facultad de Farmacia, Universidad de Costa Rica, San José 11501-2060, Costa Rica; Centro Nacional de Innovaciones Biotecnológicas (CENIBiot), CeNAT-CONARE, San José 1174-1200, Costa Rica.
Current opinion in microbiology
|October 7, 2023
概括
与Streptomyces不同的是罕见的菌体,为新型抗生素的发现提供了显著的尚未开发的潜力. 探索这些未被充分探索的细菌对于未来的抗菌药物开发至关重要.
科学领域:
- 微生物学 微生物学
- 自然产品化学 自然产品化学
- 药物发现 药物发现 药物发现
背景情况:
- 从历史上看,Streptomyces一直主导着抗生素的发现,但重新发现已知的化合物是一个越来越大的挑战.
- 奥米克斯数据和科学存储库为识别新型生物活性化合物提供了新的策略.
- 在Streptomyces属之外的罕见状菌体,因其多样化的化学和生物合成能力而越来越受认可.
研究的目的:
- 审查罕见的动因菌素的化学潜力和生物合成多样性.
- 为了评估与Streptomyces相比,在天然产品数据库中罕见的actinomycetes的代表性.
- 突出从罕见的菌素中获得的临床相关药物,并讨论未来的生物发现途径.
主要方法:
- 文献综述,重点关注罕见的形虫隔离和表征.
- 在天然产品数据库中对罕见的形虫种类表征的比较分析.
- 对已知的生物活性代谢物和由罕见的菌体产生的药物的调查.
主要成果:
- 罕见的actinomycetes具有显著的,但尚未探索的生物合成和化学多样性.
- 与Streptomyces相比,这些类型在自然产品存储库中代表性不足.
- 几种临床上有用的药物来源于罕见的形虫物种,证明了它们的治疗价值.
结论:
- 罕见的菌体代表着新型抗生素发现的前沿.
- 需要对这些生物体进行进一步的研究和专注的生物发现工作.
- 开发罕见的菌素的化学潜力对于打击抗菌素耐药性至关重要.
相关概念视频
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