在患者子组中,丸激素治疗的症状益处:系统性审查,个人参与者数据元分析和总数据元分析
Jemma Hudson1, Moira Cruickshank1, Richard Quinton2
1Health Services Research Unit, University of Aberdeen, Aberdeen, UK.
The lancet. Healthy longevity
|October 7, 2023
概括
丸激素治疗可以改善40岁以上男性的勃起功能,这些男性的丸激素水平较低,无论年龄或肥胖程度如何. 然而,老年男性和肥胖者可能达到较低的绝对性功能水平.
科学领域:
- 内分泌学 在内分泌学.
- 男人的健康 男人的健康
- 性医学性医学性医学性医学
背景情况:
- 替代疗法 (TRT) 有益于患有阴道腺缺陷症的年轻男性.
- 在老年男性和肥胖男性中,TRT的有效性不太清楚.
- 对这些人群的TRT处方增加需要进一步的研究.
研究的目的:
- 评估TRT在特定男性子组中的症状益处.
- 评估TRT对性功能,生活质量和心理结果的影响.
- 为了确定年龄,肥胖或基线水平是否会影响TRT的益处.
主要方法:
- 随机对照试验的系统审查和元分析.
- 包括18岁以上的男性,血清总丸激素<12nmol/L.
- 单个参与者数据的元分析 (17项试验,3431名参与者) 和两个阶段的元分析.
主要成果:
- 与安慰剂相比,TRT显著改善了勃起功能 (IIEF-15分数).
- 无论年龄,肥胖,糖尿病或基线水平,都观察到好处.
- TRT改善了老年男性的症状和一些生活质量得分,但没有改善心理症状.
结论:
- 短期至中期TRT为40岁以上男性低丸激素的轻度勃起功能障碍提供了临床上有意义的改善.
- 在不同年龄,肥胖状况和水平上,TRT的益处是一致的.
- 老年男性和肥胖男性的绝对性功能结果可能较低,由于基线严重程度.
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