相关实验视频
Updated: Jul 14, 2025
09:09
In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
1.8K
针对心脏代谢疾病的精准医学:临床翻译的框架
Paul W Franks1, William T Cefalu2, John Dennis3
1Department of Translational Medicine, Medical Science, Novo Nordisk Foundation, Hellerup, Denmark; Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Malmö, Sweden; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK; Harvard T H Chan School of Public Health, Boston, MA, USA.
The lancet. Diabetes & endocrinology
|October 7, 2023
概括
精准医学提供了一种强大的方法,通过整合诊断,预测,预防,预后,治疗和监测来对抗心脏代谢疾病. EPPOS模型为其在研究和临床实践中成功实施提供了一个框架.
科学领域:
- 心脏病学 心脏病学
- 代谢疾病 代谢疾病
- 基因组学就是基因组学.
- 个性化医疗是个性化的医疗.
背景情况:
- 心脏代谢性疾病对全球健康构成重大挑战.
- 精准医学可以减轻这些复杂疾病的负担.
- 目前基于证据的医学可以通过精确的方法来增强.
研究的目的:
- 概述一个将精准医学整合到心脏代谢疾病研究和临床实践中的模型.
- 将精准医学在诊断,预测,预防,预后,治疗和监测中的作用置于背景.
- 促进科学发现转化为临床实践.
主要方法:
- 介绍了EPPOS (基于证据,预测,预防,预后和分层) 模型.
- 整合精确和个性化医学的原则.
- 考虑必要的基础设施,包括数据系统和队列研究.
主要成果:
- EPPOS模型建立在基于证据的方法之上.
- 精准医学对患者进行分层,以改善预测和量身定制的治疗.
- 个性化医学使用个人数据进行客观的治疗评估和主观的决策.
结论:
- 精准医学需要一个涉及多方利益相关者的协作系统.
- 强大的数据基础设施和精心设计的研究对于精准医学至关重要.
- 为整合精准医学在心脏代谢性疾病护理中提出了一个全面的框架.
相关概念视频
01:29Cardiomyopathy V: Interprofessional Care
14
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
14
01:31Translation
142.1K
Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of...
142.1K