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警觉大鼠中多个神经调节系统的激活,获得了由正子发射断层扫描揭示的有条件的味觉厌恶

Satomi Kobayashi¹, Mie Kajiwara², Yilong Cui³

¹Department of Pharmacology, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8310, Japan; Department of Biology, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-8310, Japan.

|October 7, 2023

概括

有条件的味觉厌恶 (CTA) 检索激活了产生神经调节器和疼痛信号的大脑区域. 这项研究使用了 (18) F-氧葡萄糖-子发射断层扫描 (FDG-PET) 在老鼠,以绘制这些全脑活动.

科学领域:

神经科学是一个神经科学.
行为神经科学行为神经科学
神经成像是一种神经成像.

背景情况:

有条件的味觉厌恶 (CTA) 对于安全的食至关重要,涉及复杂的神经调节系统.
之前的研究缺乏全面了解CTA期间全脑活动.
多巴胺,上腺素,血清素和乙胆在CTA中的确切作用尚不清楚.

研究的目的:

为了研究底层的神经机制检索过程的有条件的味道厌恶 (CTA).
使用FDG-PET在CTA检索期间绘制全脑代谢活动的地图.
阐明神经调节和与疼痛相关的系统对CTA记忆回忆的贡献.

主要方法:

在老鼠中通过将糖 (IOAS) 与LiCl注射配对来确立CTA.
使用 (18) F-氧葡萄糖-正子发射断层扫描 (FDG-PET) 来图像大脑活动.
在检索阶段,CTA和SHAM组之间的脑活动比较.

主要成果:

在CTA检索中,神经调节器产生的区域 (黑质体,腹膜区域,角质位,背部角质,基底细胞核) 和海马体的FDG吸收增加.
来自LiCl注射的内脏疼痛激活了体感皮层和岛屿皮层,以及与疼痛相关的脑干细胞核 (双臂,单独).
FDG-PET揭示了CTA获取与内脏疼痛诱导之间脑激活的不同模式.

结论:

CTA检索涉及到负责神经调节器生产的大脑区域的激活.
大脑干中的疼痛处理途径也与CTA记忆回忆有关.
FDG-PET成像为CTA检索的神经回路提供了宝贵的见解.

关键词:

图像成像是一种成像.记忆记忆记忆记忆记忆神经调节器是一种神经调节器.检索检索可以检索.味道厌恶的学习学习.

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