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同时的TMS/fMRI揭示了个别DLPFC的剂量反应模式.

Martin Tik1, Maria Vasileiadi2, Michael Woletz2

  • 1MR Center of Excellence, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Lazarettgasse 14, Vienna 1090, Austria; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA, USA.

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概括

在脊侧前额叶皮层 (DLPFC) 调查跨磁刺激 (TMS) 的剂量反应,发现了显著的个体变异性. 同时的TMS/fMRI可以通过针对抑郁症等疾病的个性化刺激强度来优化治疗.

关键词:
剂量反应对剂量的反应.兴奋能力 兴奋能力这是TMS-fMRI.这是一个值.通过骨磁刺激进行磁性刺激.

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科学领域:

  • 神经科学是一个神经科学.
  • 精神病学是一个精神病学.
  • 医疗成像医学成像

背景情况:

  • 超磁刺激 (TMS) 对于理解大脑行为联系和治疗神经/精神疾病至关重要.
  • 左背侧前额皮层 (DLPFC) TMS是一种FDA批准的治疗主要抑郁症 (MDD) 的方法.
  • 对TMS反应的变化,通常是由于刺激强度,这构成了重大的临床挑战.

研究的目的:

  • 为了在DLPFC中建立TMS的剂量反应关系,使用并发的TMS/fMRI.
  • 为了研究不同的刺激强度如何影响大脑活动.

主要方法:

  • 15名受试者同时接受了80%,90%,100%和110%的运动值的TMS/fMRI.
  • 数据收集包括用于神经导航的解剖扫描和用于剂量反应映射的功能扫描.
  • 对于每个强度的个体受试者和小组级分析,计算了通用线性模型 (GLMs).

主要成果:

  • 组级分析表明,在100%的刺激强度下,最强的血氧水平依赖 (BOLD) 反应.
  • 个体分析揭示了多种多样的剂量反应模式,包括对下值,上值和非典型刺激水平的反应.
  • 观察到DLPFC TMS反应的显著个体间变异.

结论:

  • 个别的运动值可能无法直接预测DLPFC兴奋度,这凸显了对个性化TMS协议的需求.
  • 同时的TMS/fMRI显示出在重复性TMS (rTMS) 应用中改善响应率的希望.
  • 未来的研究应该探索实施TMS/fMRI或为优化临床TMS剂量和向提供具有成本效益的替代方案.