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在过度活跃的膀中使用甲福明:一个追溯的嵌套病例控制,基于人口的分析分析
Sarah Neu1, Rano Matta1, Jennifer A Locke1
1Division of Urology, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Urology
|October 7, 2023
概括
在患有2型糖尿病的老年患者中,甲福明的使用与过度活性膀 (OAB) 药物使用率略高相关,这表明没有保护作用. 这一发现挑战了甲福明的潜在OAB益处.
科学领域:
- 老年学是指老年学的学科.
- 药理学 药理学是指药理学的学科.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 甲胺是一种常见的糖尿病药物,在动物模型中显示出改善膀过活性的潜力.
- 过度活性膀 (OAB) 是一种常见的疾病,影响着老年人,通常用药物治疗.
研究的目的:
- 调查二型糖尿病 (DM2) 的老年患者的甲福明使用与过度活性膀 (OAB) 药物使用率之间的关联.
主要方法:
- 使用大型医疗保健行政数据库进行了回顾性嵌套病例控制队列研究.
- 包括69岁及以上的DM2患者,其中接受OAB药物处方的病例与对照组相匹配.
- 在OAB药物之前的甲福明处方被评估为暴露,并计算了调整后的几率比率.
主要成果:
- 分析了2,233,084名患有DM2的患者队列,确定了16,549例和64,171例对照.
- 甲胺使用与OAB药物使用有轻微的积极关联 (aOR=1.07,95%CI=1.03-1.12).
- 这种关联持续到累积的甲福明供应超过2220天,之后没有发现任何显著的关联.
结论:
- 在患有DM2的老年患者中,甲福明的使用与OAB药物使用率略有增加有关.
- 这些发现不支持甲胺在预防OAB中发挥保护作用.
- 与长时间使用甲福明 (>2220天) 没有观察到任何关联.
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