日本男性的肠道微生物群和冠状动脉化
Yukiko Okami1, Hisatomi Arima2, Keiko Kondo3
1NCD Epidemiology Research Center, Shiga University of Medical Science, Otsu, Japan..
American heart journal
|October 7, 2023
概括
肠道微生物组成的变化与冠状动脉化 (CAC) 相关联,甚至在冠状动脉疾病 (CAD) 诊断之前. 特定的细菌群体,如Firmicutes和Streptococcus,与增加的CAD风险和CAC得分有关.
科学领域:
- 微生物组研究的研究.
- 心血管疾病流行病学
- 预防性心脏病学 预防性心脏病学
背景情况:
- 在冠状动脉疾病 (CAD) 患者中观察到肠道微生物群的改变.
- 在CAD发病前存在这些肠道微生物差异的存在尚不清楚.
- 在亚临床冠状动脉化 (CAC) 中调查肠道微生物群可以揭示早期疾病标志物.
研究的目的:
- 在日本人群中检查肠道微生物组成和亚临床冠状动脉化 (CAC) 之间的关联.
- 确定肠道微生物差异是否先于冠状动脉疾病 (CAD) 的临床表现.
- 确定与CAC.的存在和严重程度相关的特定细菌种群.
主要方法:
- 对663名日本男性进行横截面研究.
- 使用计算机断层扫描和阿加斯顿方法评估冠状动脉化 (CAC).
- 通过16S核糖体RNA基因测序和生物信息学工具 (QIIME2,LEfSe) 分析肠道微生物群组成.
主要成果:
- Firmicutes 与 Bacteroidota 的比率在较高的 CAC 评分和在有 CAD 病史的参与者中增加.
- 高水平的Firmicutes,Bacilli和Lactobacillales与1.3至1.4倍增加的CAD风险有关.
- 包括Streptococcaceae,Streptococcus,Enterobacterales和Enterobacteriaceae在内的特定类型与CAC分数和CAD风险存在相关性,而Blautia则表明它们具有保护作用.
结论:
- 肠道微生物群的组成根据CAC得分有显著的变化,这表明在CAD临床发病之前就存在关联.
- 这些发现凸显了肠道微生物群作为心血管风险早期指标的潜力.
- 对调节肠道微生物群的进一步研究可能为CAD预防提供新的策略.
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