饮食中的蛋白质限制通过纤维细胞生长因子21 (FGF21) 调节饭后的"甜点"摄入量
Chih-Ting Wu1, Karlton R Larson1, Landon C Sims1
1Department of Neurobiology, Physiology and Behavior, College of Biological Sciences, University of California, One Shields Avenue, 196 Briggs Hall, Davis, CA 95616, USA.
Physiology & behavior
|October 7, 2023
概括
低蛋白饮食会增加纤维细胞生长因子21 (FGF21),但不会减少甜食摄入量. 然而,这种饮食增加了雄性小鼠的蛋白质颗粒消耗,这取决于FGF21信号.
科学领域:
- 代谢和内分泌学
- 营养神经科学 营养神经科学
- 动物模式的饮食和行为.
背景情况:
- 纤维细胞生长因子21 (FGF21) 在药理上降低了甜食偏好.
- 内生FGF21分泌,特别是来自肝脏的,受饮食中的宏观营养素组成的影响,特别是蛋白质与能量比率 (P:E).
- 目前正在探索针对FGF21的饮食策略,以调节食物选择并促进更健康的饮食模式.
研究的目的:
- 为了研究低P:E预负载饮食是否会增加内源性FGF21,从而减少随后的甜点消费.
- 为了确定FGF21是否会在低P:E预负载后促进高蛋白小吃摄入量的增加.
- 检查性别差异和肝脏FGF21在这些饮食反应中的作用.
主要方法:
- 雄性和雌性C57Bl/6J小鼠和肝部特异性FGF21-null (FGF21ΔL) 小鼠被食控制或低P:E饮食.
- 在预装餐后,小鼠被提供甜的溶液或高蛋白质颗粒作为"甜点".
- 测量了血FGF21水平和甜点的消耗.
主要成果:
- 低P:E预负荷饮食强烈增加了血FGF21水平,但没有降低随后的甜味溶液摄入量.
- 相反,低的P:E预负荷增加了高蛋白质颗粒的消耗,这种效应在雄性小鼠中更为明显.
- 高蛋白质颗粒摄入量的增加在FGF21ΔL小鼠中被取消,证实了FGF21的作用.
结论:
- 低蛋白饮食对肝脏FGF21的生理诱导不足以减少甜食消费.
- 低蛋白饮食有效地增加了男性小鼠随后的食蛋白摄入量,由FGF21调解.
- 这些发现强调了FGF21,饮食和宏观营养素特定的食物选择之间的复杂相互作用.
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