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皮肤透研究的Strat-M®定位:包括EpiSkin® RHE和人类皮肤在内的比较研究

Hichem Kichou¹, Franck Bonnier², Yuri Dancik³

¹Université de Tours, EA 6295 Nanomédicaments et Nanosondes, Faculté de Pharmacie, 31 Avenue Monge, 37200 Tours, France.

International journal of pharmaceutics

|October 7, 2023

概括

斯特拉特-M®是一种新的膜,可以有效地模仿人体皮肤进行体外透测试. 它独特的结构为皮肤病产品的开发和测试提供了更现实的障碍.

科学领域:

皮肤科学皮肤科学
材料科学材料科学材料科学
药理动力学药理动力学

背景情况:

在体外透测试 (IVPT) 对于皮肤产品开发至关重要.
标准化和人类皮肤复制是IVPT的关键挑战.
重建的人体皮肤和合成膜被探索为替代品.

研究的目的:

评估Strat-M®作为IVPT的合成膜.
为了比较Strat-M®对人类皮肤和EpiSkin® RHE的性能.
评估Strat-M®是否适合在皮肤病学研究中增强现实性和可重现性.

主要方法:

用于体外透测试 (IVPT) 的Strat-M®膜.
在Strat-M®,切割的人体皮肤和EpiSkin® RHE中测量的复苏的平稳状态流量 (JSS).
质谱和拉曼显微镜用于分子分析.
为验证而进行的相似性因子分析.

主要成果:

对于Resorcinol配方 (40-42μg/cm2·h),Strat-M®显示了比EpiSkin® RHE (138-162μg/cm2·h) 更接近切除的人体皮肤 (5-13μg/cm2·h) 的平稳状态流量.
斯特拉特-M®的多孔性和疏水性更好地复制了人类皮肤的扩散限制屏障.
类似因素分析表明,Strat-M®与人皮肤之间存在很高的一致性 (∼80-85%).

结论:

在IVPT中,Strat-M®作为人类皮肤的可靠和有效替代品.
它的结构性质提高了皮肤病产品测试的准确性和可重复性.
斯特拉特-M®为体外皮肤学研究提供了一个有前途的进步.

关键词:

切除的人类皮肤.高性能液体色谱学高性能液体色谱学人类皮肤模型脂质分析脂质分析透测定试验透测定试验拉曼光谱法拉曼光谱法拉曼光谱法重建的人类皮肤.这是一种Resorcinol.对于Strat-M®,这是一个很好的选择.

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