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在动脉样硬化中使用单细胞技术检测细胞类型丰富的长非编码RNA:简要回顾

Zhiyuan Wu¹, Huarun Yin², Yongsheng Guo³

¹Department of Vascular Surgery, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, 100730 Beijing, PR China.

|October 7, 2023

概括

本综述强调了通过在动脉样硬化中单细胞RNA测序识别的新型长非编码RNA (lncRNAs). 这些lncRNAs为诊断和治疗心血管疾病提供了潜在的新点.

科学领域:

心血管生物学和分子遗传学.

背景情况:

心血管疾病是全球主要的健康负担,动脉样硬化 (AS) 是主要的驱动因素.
动脉硬性斑块涉及复杂的细胞相互作用,包括结构细胞和免疫细胞,如巨细胞和T细胞.

结论:

在AS中注释功能性lncRNA对于推进临床实践至关重要.
鉴定到的 lncRNAs 显示了未来心血管医学诊断和治疗策略的前景.

关键词:

动脉样硬化是一种动脉样硬化.内皮细胞内皮细胞的内皮细胞.长长的非编码RNAs.单细胞RNA测序的一个细胞.血管光滑肌肉细胞细胞

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相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...