短链脂肪酸 - - 对过敏性疾病的关键干扰因素
1Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, 250012, China.
Chemico-biological interactions
|October 7, 2023
概括
肠道微生物群的不平衡与过敏有关. 由肠道细菌产生的短链脂肪酸 (SCFA) 在免疫调节中起着至关重要的作用,可能为过敏性疾病提供治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 胃肠病学 胃肠病学
背景情况:
- 过敏性疾病代表着一个显著且日益增长的全球健康负担.
- 肠道微生物群失生症越来越多地与各种过敏状况有关,包括喘和亚托邦性皮肤炎.
- 连接肠道微生物群与过敏的确切机制尚不完全理解.
研究的目的:
- 审查临床和实验证据,将短链脂肪酸 (SCFA) 与过敏性疾病联系起来.
- 探索SCFA影响过敏疾病发展和进展的潜在机制.
- 总结目前的研究和SCFA作为过敏治疗点的未来前景.
主要方法:
- 对调查肠道微生物群-过敏轴的流行病学和实验研究的审查.
- 对SCFA生物功能的文献分析,包括免疫调节和肠道平衡.
- 对基于SCFA的过敏症干预措施的研究综合.
主要成果:
- 肠道微生物群代谢物,特别是SCFA,是肠道-过敏关系中的关键调解者.
- 通过与宿主受体相互作用和调节表观遗传机制 (希斯脱乙酶抑制),SCFA具有保护作用.
- 有证据支持SCFA在维持免疫平衡和预防过敏敏感性方面的作用.
结论:
- SCFA是关键分子,将肠道微生物群与过敏性疾病的病原发生联系起来.
- 向SCFA和调节肠道微生物群代表了管理过敏的有希望的治疗策略.
- 需要进一步的研究来充分阐明SCFA机制,并优化它们在过敏治疗中的临床应用.
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