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Updated: Jul 14, 2025

Enhanced Yeast One-hybrid Screens To Identify Transcription Factor Binding To Human DNA Sequences
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Enhanced Yeast One-hybrid Screens To Identify Transcription Factor Binding To Human DNA Sequences

Published on: February 11, 2019

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转录因子结合k-mer分析澄清了人类结合特异性和cis-regulatory SNPs的细胞类型依赖性

Saeko Tahara1,2, Takaho Tsuchiya1,3, Hirotaka Matsumoto4,5

  • 1Bioinformatics Laboratory, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8577, Japan.

BMC genomics
|October 7, 2023
PubMed
概括

这项研究揭示了转录因子 (TF) 的DNA结合特异性如何因细胞类型而异,使用基于k-mer的方法. 这些发现有助于理解基因调节,并识别影响TF结合的疾病相关变异.

关键词:
细胞类型依赖性 细胞类型依赖性在 ChIP-seqq.结合DNA的动机是结合DNA的动机.不同的k-mer分析.功能性基因组学是一种功能性基因组学.在GWAS-SNP之间.监管SNP的SNP是一个规范性的SNP.转录因子是一种转录因子.基于k-mer的分析

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