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评估病毒载量抑制和报告死亡的性别差异,使用从撒哈拉以南非洲的PEPFAR支持国家例行收集的计划数据

Danielle Fernandez^1,2, Hammad Ali³, Sherri Pals³

¹Public Health Institute (PHI), CDC Global Health Fellowship Program, Atlanta, USA. pui6@cdc.gov.

BMC public health

|October 7, 2023

概括

撒哈拉以南非洲的男性在接受抗逆转录病毒疗法 (ART) 的死亡率更高,尽管病毒载量抑制 (VLS) 与女性相似. 需要进一步的研究来了解这些在艾滋病毒治疗结果的差异.

科学领域:

公共卫生公共卫生
传染性疾病传染性疾病
流行病学流行病学

背景情况:

撒哈拉以南非洲地区对妇女的艾滋病毒检测和治疗机会更高.
女性可能比男性更好地实现病毒载荷抑制 (VLS).
这项研究研究了VLS的性别差异和艾滋病毒计划中的死亡率.

研究的目的:

分析病毒载量抑制 (VLS) 和死亡率的基于性别的差异.
调查撒哈拉以南非洲地区接受抗逆转录病毒疗法 (ART) 的个体的结果.
为改善男性艾滋病毒治疗结果提供有针对性的干预措施.

主要方法:

利用来自21个撒哈拉以南非洲国家的常规报告的艾滋病毒计划数据.
包括15岁以上接受ART治疗的人群的VLS和死亡数据 (2020年10月至12月),按性别和年龄分类.
采用线性混合模型和负二项式混合模型回归,对关键共变量进行调整.

主要成果:

与男性 (92.0%) 相比,女性的平均VLS (93.0%) 较高.
男人报告死亡的平均比率 (2.37对1.51每1000人) 和死亡加治疗中断的平均比率 (30.1对26.0每1000人) 显著更高.
即使在调整为VLS之后,男性的死亡率仍然较高.

结论:

在撒哈拉以南非洲,无论VLS,男性在ART的死亡率更高.
调查男性寻求护理,机会性感染管理和测试可访问性的差异至关重要.
建议包括加强男性的测试选择,如CD4计数监测.

关键词:

在治疗中断.死亡率死亡率死亡率这就是PEPFAR.性差异性差异性差异性差异性差异性差异性差异性病毒抑制病毒抑制

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