高风险HPV的流行病学特征以及多种感染和宫病变之间的相关性
Qinli Luo1, Xianghua Zeng2, Hanyi Luo2
1Chongqing Cancer Multi-Omics Big Data Application Engineering Research Center,, Chongqing University Cancer Hospital, 181 Hanyu Road, Shapingba District, Chongqing, 400030, China. m13668488467@163.com.
BMC infectious diseases
|October 7, 2023
概括
多重高危人乳头瘤病毒 (HR-HPV) 感染增加了宫病变的风险,如低级皮内皮病变 (LSIL) 和高级皮内皮病变 (HSIL). 这项研究强调HPV-33和HPV-58是需要监测的潜在高风险类型.
科学领域:
- 妇科 妇科 妇科 妇科
- 病毒学 病毒学
- 在瘤学瘤学.
背景情况:
- 高危人乳头瘤病毒 (HR-HPV) 是导致子宫癌的主要原因.
- 了解多个HR-HPV基因型的患病率和影响对于宫癌预防策略至关重要.
研究的目的:
- 在大量女性中确定HR-HPV感染的流行率.
- 调查多个HR-HPV基因型感染与宫病变的存在和严重程度之间的相关性.
- 确定特定的HR-HPV基因型和与宫内皮质瘤和癌症风险增加相关的同时感染模式.
主要方法:
- 分析了20059名接受子宫部查的妇女的基于人口的样本.
- 使用ThinPrep细胞检测 (TCT) 来检测15种HR-HPV基因型.
- 进行了统计分析,包括几率比率 (ORs) 和附加统计相互作用的评估,以评估共感染模式及其与宫病变的关联.
主要成果:
- 多个HR-HPV感染表现出双模流行模式,在年轻女性和老年女性中达到顶峰.
- 在高度状内皮病变 (HSIL) 和宫癌病例中,HPV-16是最常见的类型.
- 与单次感染女性相比,患有多次HR-HPV感染的女性的低级状内皮病变 (LSIL) (OR=2.01) 和HSIL (OR=2.28) 的风险明显增加. 宫癌患者的多重HPV感染率也更高.
- 确定HPV-33和HPV-58是潜在的高风险类型,需要进一步监测.
结论:
- 多重HR-HPV感染与LSIL和HSIL的相关性比单次感染更强.
- HR-HPV基因型的特定组合可以协同增加发展HSIL和LSIL的风险.
- 这些发现支持加强对HPV-33和HPV-58的监测,因为它们与子宫病变有关.
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