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Updated: Jul 14, 2025

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用MRE11和EXO1核酶对复制应激衍生的新生链DNA缺口进行多步处理

Anastasia Hale1, Ashna Dhoonmoon1, Joshua Straka1

  • 1Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.

Nature communications
|October 7, 2023
PubMed
概括

在复制过程中形成的单链DNA (ssDNA) 缺口通过核分解处理转化为DNA双链断裂 (DSB). 这种机制受到BPA和DEHP等环境污染物的影响,导致基因组不稳定.

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