稳定肠道巨细胞中释放的组胺可缓解中风后的外周和中心炎症
Maria P Blasco Conesa1, Frank W Blixt1, Pedram Peesh1
1Department of Neurology, The University of Texas McGovern Medical School, Houston, TX, 77030, USA.
Journal of neuroinflammation
|October 7, 2023
概括
克罗莫林 (Cromolyn) 是一种巨细胞稳定剂,通过防止组胺释放,减少了脑炎症,并改善了中风后的功能结果. 这项研究强调了巨细胞.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 卒中是导致残疾的主要原因,其结果受到缺血损伤和全身炎症的影响.
- 巨细胞 (MCs) 释放 histamine,一种促炎媒介,并与中风后的炎症有关.
- 肠道是一个重要的基因组胺储存库,这表明潜在的肠-大脑轴参与中风.
研究的目的:
- 为了研究巨细胞在缺血性中风后的神经炎症中的作用.
- 为了确定cromolyn,一个巨细胞稳定剂,可以改善功能结果和减少中风后的神经炎症.
主要方法:
- 在老年雄性小鼠中使用过渡性中脑动脉封闭 (MCAO) 模型.
- 在MCAO后的各种时间点口服克罗莫林.
- 评估了巨细胞数量,心脏病发作量,功能结果,血细胞因子水平和肠道屏障完整性.
主要成果:
- 克罗莫林显著降低了大脑和肠道中巨细胞的数量.
- 在接受cromolyn治疗的小鼠中观察到改善的功能结果,尽管心脏病发作量没有显著变化.
- 克罗莫林治疗降低了血组胺和IL-6水平,改善了肠道屏障的完整性,并减轻了中风诱导的功能失调.
结论:
- 通过使用cromolyn防止杆细胞的组胺释放,可以减轻中风后的神经炎症.
- 克罗莫林的使用改善了缺血性中风后的神经和功能结果.
- 乳腺细胞稳定代表了中风恢复的潜在治疗策略.
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