与药物相关的下巴骨髓硬化是否会影响多发性骨髓瘤患者的存活率? :使用人工智能探索一个大型单一中心数据库
Max Bittrich1, Regina Hetterich2, Antonio G Solimando3
1Department of Internal Medicine II, University Hospital Würzburg, 97080, Würzburg, Germany. Bittrich_M@ukw.de.
Clinical and experimental medicine
|October 7, 2023
概括
在一项研究中,与药物相关的下骨硬化 (MRONJ),在多发性骨髓瘤 (MM) 患者中是一种罕见的副作用,与更长的整体存活率有关. 尽管患者往往具有更糟糕的临床特征,但这一发现却出现了.
科学领域:
- 在瘤学瘤学.
- 现实世界的证据.
- 医疗信息学 医疗信息学
背景情况:
- 现实世界证据 (RWE) 对于了解随机试验之外的临床实践至关重要,特别是在多发性骨髓瘤 (MM) 等罕见疾病中.
- 与药物相关的骨 (MRONJ) 是一种罕见但重要的不良事件,与MM患者的骨保护治疗有关.
- 对于MRONJ对MM预后和患者结局的影响仍然不太清楚,需要进一步调查.
研究的目的:
- 调查与药物相关的下骨硬化 (MRONJ) 对多发性骨髓瘤 (MM) 患者的预后和生存的长期影响.
- 利用人工智能和自然语言处理 (NLP) 在大型数据集中有效识别患有罕见疾病和不良事件的患者.
主要方法:
- 采用了回顾性研究设计,使用了2389名多发性骨髓瘤 (MM) 患者的大队列.
- 使用自然语言处理 (NLP) 来选患者数据以识别与药物相关的骨 (MRONJ) 病例.
- 进行了倾向性得分匹配,以提高数据质量和控制患者组比较时的混因素.
主要成果:
- 在2389名MM患者中,有50人被确诊患有与药物相关的下巴骨硬化 (MRONJ),符合纳入标准.
- 与没有MRONJ的患者相比,患有MRONJ的多发性骨髓瘤 (MM) 患者的整体存活时间明显更长 (中位数为126个月与86个月).
- 尽管MRONJ患者队列的基线临床特征略有恶化,但观察到这种生存益处.
结论:
- 与药物相关的下骨硬化 (MRONJ) 可能与多发性骨髓瘤 (MM) 患者的长期存活率的改善有关.
- 该研究强调了人工智能和NLP在分析罕见不良事件的真实世界数据方面的实用性.
- 需要进一步的研究,以阐明MRONJ与MM生存率的增强之间观察到的关联背后的机制.
关键词:
人工智能的人工智能是人工智能.多发性骨髓瘤是多发性骨髓瘤的一种.自然语言处理自然语言处理.骨缩的部骨髓缩的情况倾向性得分匹配的匹配方法罕见不良事件 罕见的不良事件罕见疾病是一种罕见的疾病.现实世界的证据 现实世界的证据更多相关视频
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