无症状动脉样硬化和hepcidin-25在慢性病患者之间的关系
Osama Nady Mohamed1, Ahmed Mohamed Mady1, Mohamed Mamdouh Sedik1
1From the Department of Internal Medicine, Faculty of Medicine, Minia University, Minia, Egypt.
Annals of Saudi medicine
|October 8, 2023
概括
血清肝素-25 (SH-25) 是慢性病 (CKD) 患者无症状动脉样硬化的可靠预测剂. 较高的SH-25水平与动脉内膜介质厚度 (CIMT) 的增加相关,这表明它在疾病进展中起着至关重要的作用.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 心脏病学 心脏病学
- 生物标志物发现发现
背景情况:
- 动脉样性心血管疾病是慢性病 (CKD) 死亡的主要原因.
- 慢性瘤的炎症会提高肝素水平,动脉中的铁积累与动脉样硬化有关.
- 正在研究素-25通过影响巨细胞铁释放来加速斑块发育的作用.
研究的目的:
- 为了研究血清肝素-25 (SH-25) 和亚临床动脉样硬化之间的关系.
- 评估SH-25作为非透析CKD患者无症状动脉样硬化的潜在生物标志物.
主要方法:
- 一项涉及128名参与者的横截面研究 (25个对照组,103名非透析CKD患者).
- 评估SH-25的血清水平,炎症标志物 (IL-6,TNF-α,hs-CRP) 和脂质.
- 通过心血管超声扫描测量了心血管内膜介质厚度 (CIMT) 和斑块的存在.
主要成果:
- 与对照组相比,CKD患者表现出较高的炎症标志物和改变的脂质谱.
- 在CKD患者中,血清肝素-25 (SH-25) 度显著升高,随着CKD进展而增加.
- 在CKD患者中增加了CIMT,与SH-25,IL-6,TNF-α和hs-CRP正相关.
结论:
- 在CKD患者中,SH-25和CIMT之间存在显著的积极关系.
- 正如ROC曲线分析所示,SH-25对动脉样硬化具有很强的预测价值.
- 建议SH-25作为检测CKD无症状动脉样硬化的重要生物标志物.
相关概念视频
01:25Chronic Kidney Disease I: Introduction
19
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage kidney disease (ESKD). At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate...
19
01:24Chronic Kidney Disease II: Clinical Manifestations
13
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
13
01:28Chronic Kidney Disease III: Interprofessional Care
26
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
26
01:30Acute Kidney Injury IV: Diagnostic Studies and Prevention
21
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
21
01:28Kidney Transplant I: Introduction
14
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
14
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
101
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
101