[在癌症治疗中向异构体的蛋白质分解的有针对性输送方面取得的进展]

Xiaobo Wu1,2, Jie Zhao1,2, Yuan Gao2

  • 1School of Materials Science and Engineering, Central South University of Forestry and Technology, Changsha 410004, Hunan, China.

概括

针对蛋白质溶解的嵌合体 (PROTAC) 通过降解瘤原蛋白来提供一种新的癌症治疗策略. 有针对性的输送系统可以提高PROTAC的疗效,选择性和安全性,从而改善治疗结果.

相关概念视频

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.7K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K