特定站点的交叉连接显示,酸果酸酶-L抑制驱动自我组装和减弱蛋白相互作用

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Updated: Jul 14, 2025

Monitoring the Assembly of a Secreted Bacterial Virulence Factor Using Site-specific Crosslinking
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Monitoring the Assembly of a Secreted Bacterial Virulence Factor Using Site-specific Crosslinking

Published on: December 17, 2013

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Athira Sivadas1, Eli Fritz McDonald2, Sydney O Shuster3

  • 1Department of Chemistry, Vanderbilt University, Nashville, TN, USA.

Advances in biological regulation
|October 8, 2023
PubMed
概括

肝脏果酸酶 (PFKL) 分区,在酸盐抑制过程中形成点. 这种隔离会影响2界面上的蛋白相互作用,这表明它在代谢调节中的作用.

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Ligand Binding and Linkage00:49

Ligand Binding and Linkage

Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
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