免疫球蛋白水平在多发性硬化症发病时较高 - - 是自然史的一部分吗?
Mickael Bonnan1, Henri Courtade2, Stéphane Debeugny3
1Service de neurologie, Hôpital Delafontaine, Saint-Denis 93200, France.
Multiple sclerosis and related disorders
|October 8, 2023
概括
免疫球蛋白G (IgG) 水平在多发性硬化症 (MS) 诊断时暂时较高. 这些水平在整个疾病过程中保持稳定,无论疾病修饰药物或皮质类固醇.
科学领域:
- 神经免疫学 神经免疫学
- 临床免疫学临床免疫学
- 神经学 神经学
背景情况:
- 免疫球蛋白 (Ig) 水平可以通过治疗多发性硬化症 (MS) 来改变,例如疾病修饰药物 (DMD) 和皮质类固醇 (CS).
- 在没有治疗干预的情况下,MS患者Ig水平的自然进展尚不清楚.
研究的目的:
- 在患有多发性硬化症 (MS) 的患者中调查免疫球蛋白水平的自然史.
主要方法:
- 一项单中心的回顾性研究分析了7年来304名连续多发性硬化症患者的1204个样本.
- 常规收集Ig水平并与皮质类固醇 (CS) 摄入量相关分析.
主要成果:
- 在诊断时观察到较高的免疫球蛋白G (IgG) 水平,与以后的时间点相比.
- 这种IgG的升高甚至存在于没有接受DMD或CS的患者中.
- 无论治疗方式如何,Ig水平在发病后1至20年内保持稳定.
结论:
- 在MS发病时IgG水平暂时升高表明早期,显著的炎症过程.
- 在MS中Ig水平的自然动态的特点是最初的峰值,然后是稳定.
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