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阿根廷神经炎光学谱系障碍:一项医院研究

Andrés M Villa¹, Analisa Manin¹, Carla Seimandi¹

¹División Neurología, Facultad de Medicina, Hospital General de Agudos Dr. José María Ramos Mejía, Buenos Aires, Argentina; Centro Argentino de Neuroinmunología (CADENI), Universidad de Buenos Aires, Buenos Aires, Argentina.

Multiple sclerosis and related disorders

|October 8, 2023

概括

神经omyelitis光谱障碍 (NMOSD) 是一种自身免疫性中枢神经系统疾病,影响视神经和脊髓. 这项研究强调了早期发病,AQP4-IgG+患者的女性患病率,以及阿根廷NMOSD患者的复发性疾病.

科学领域:

神经免疫学神经免疫学
自免疫性疾病自免疫性疾病
中枢神经系统疾病中枢神经系统疾病

背景情况:

神经omyelitis光谱障碍 (NMOSD) 是一种抗体介导的自身免疫性疾病,向中枢神经系统,特别是视神经和脊髓.
关于拉丁美洲 (LATAM) 的NMOSD存在有限的数据,很少有发表的报告.
这项研究主要集中在阿根廷的一个中心描述NMOSD.

研究的目的:

描述阿根廷92名NMOSD患者的临床,实验室,MRI,残疾过程和治疗.
为了解拉丁美洲环境中的NMOSD做出贡献.
在医院基队列中确定NMOSD的关键特征.

主要方法:

在阿根廷布宜诺斯艾利斯的一个参考中心进行的回顾性横截面研究.
从2000年1月到2021年12月从92名NMOSD患者的医疗记录中收集的数据.
分析包括临床表现,实验室结果,MRI发现,残疾状态 (EDSS) 和治疗方案.

主要成果:

发病时的平均年龄为31岁,女性/男性比例为4.8:1. 早期发病 (<50岁) 发生在71.7%的患者中.
视神经炎 (47.8%) 和横髓炎 (33.7%) 是最常见的初始症状. 96.7%的人经历了复发.
78.6%的测试结果对AQP4-IgG呈阳性. 常见的治疗方法包括Rituximab和阿扎西奥普林.

结论:

这是阿根廷最大的NMOSD医院研究,揭示了复发性疾病和早期发病作为突出的特征.
在AQP4-IgG阳性患者中观察到女性患病率.
需要在阿根廷和拉美地区进行进一步的研究,以提高对NMOSD的理解和治疗策略.

关键词:

在AQP4-IgG中,它是AQP4-IgG.阿根廷阿根廷阿根廷阿根廷阿根廷.人口统计学人口统计学拉丁美洲拉丁美洲拉丁美洲神经炎视觉谱系障碍视觉谱系障碍

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