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低维生素D状态,血清激素和阿尔茨海默氏病的临床生物行为参数之间的关联

Anna-Lena Richter¹, Marlies Diepeveen-de Bruin¹, Michiel G J Balvers¹

¹Division of Human Nutrition and Health, Chair Group Nutritional Biology, Wageningen University and Research (WUR), Wageningen, The Netherlands.

Dementia and geriatric cognitive disorders

|October 8, 2023

概括

阿尔茨海默病 (AD) 患者的维生素D水平较低与较低的血清素和较高的粉样β水平有关. 这些发现表明,维生素D可能会影响AD的进展和症状.

科学领域:

神经科学是一个神经科学.
生物化学生物化学
老年学是一门学科.

背景情况:

维生素D在阿尔茨海默病 (AD) 进展和症状中的潜在作用是由体外研究表明的.
有限的体内数据存在于维生素D与AD患者的认知功能以及痴呆症 (BPSD) 的行为和心理迹象和症状的关联.

研究的目的:

在阿尔茨海默氏症患者中,研究血清25-基维生素D3 (25(OH) D3) 水平和血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清中血清.
为了探索维生素D缺乏症在阿尔茨海默病患者队列中的患病率.

主要方法:

对25名具有良好的特征的阿尔茨海默病患者进行了回顾性横截面研究.
通过LC-MS/MS分析血清25(OH) D3,通过竞争ELISA分析血清5-HT.
对年龄,性别和精神药物进行调整的回归分析.

主要成果:

在AD患者中,维生素D缺乏的高患病率 (水平<50nmol/L).
血清25(OH) D3和5-HT水平之间的积极关联 (p = 0.012).
血清25(OH) D3和CSF粉样蛋白-β (Aβ1-42) 水平之间的反相关性 (p = 0.006).
血清5-HT与侵略性,正面行为,抑郁症和认知表现有积极的相关性.
服用胆酶抑制剂的AD患者的血清25(OH) D3水平较高,血清5-HT水平较低.

结论:

在AD中观察到低维生素D状态,血清5-HT和CSF Aβ1-42水平之间的显著分子关联.
这些发现突出了涉及维生素D在AD临床生物行为病理生理学中的潜在机制.
需要进一步的机制和干预研究来探索维生素D在阿尔茨海默病中的作用.

关键词:

25 基维生素 D3 的含量阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.是由42个氨基酸组成的氨基酸β.痴呆症的行为和心理迹象和症状.这是一种血清胺.

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