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长非编码RNA作为非酒精性脂肪肝疾病 (NAFLD) 的调制剂和治疗点

Qing Tao¹, Jing Xie¹, Yongkang Wu¹

¹Inflammation and Immune-Mediated Diseases Laboratory of Anhui Province, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China.

Gastroenterologia y hepatologia

|October 8, 2023

概括

非酒精性脂肪性肝病 (NAFLD) 涉及不完全理解的分子过程. 本综述探讨了长非编码RNA (lncRNAs) 如何促进NAFLD进展,提供了对潜在治疗方法的见解.

科学领域:

肝病学肝病学是一种肝病学.
分子生物学分子生物学
基因组学就是基因组学.

背景情况:

非酒精性脂肪性肝病 (NAFLD) 影响全球25%,从肥胖症发展为肝硬化或肝细胞癌 (HCC).
导致NAFLD进展的分子机制尚不完全理解.
长非编码RNAs (lncRNAs) 越来越多地被认为是它们在各种生物过程中的角色.

研究的目的:

提供NAFLD和lncRNAs的概述.
总结 lncRNA 作用在 NAFLD 发展中的机制.
讨论 lncRNAs 对NAFLD 的未来治疗潜力.

主要方法:

对NAFLD和lncRNAs现有研究的文献综述.
对lncRNA参与肝脂代谢,NASH,纤维化和HCC的分析.
对NAFLD病变发生过程中的lncRNA机制的当前知识的综合.

主要成果:

LncRNAs参与调节NAFLD的关键信号通路.
研究表明,lncRNA表达和NAFLD阶段之间存在强烈的相关性.
LncRNAs影响肝脏脂质代谢,炎症,纤维化和HCC发育.

结论:

LncRNAs在NAFLD的分子病变发生中发挥着重要作用.
了解ncRNA功能对于阐明NAFLD进展至关重要.
对于新的NAFLD治疗策略来说,LncRNAs是一个有前途的目标.

关键词:

没有编码的RNA largos.戴安娜的治疗方法肝脏疾病脂肪没有酒精长长的非编码RNAs.机械主义的机制机理机制机理机制非酒精性脂肪性肝病是非酒精性脂肪性肝病.治疗目标治疗目标

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