由环境丰富引起的记忆持久性取决于不同的大脑结构.
Eduarda G Nachtigall1, Júlia D R de Freitas1, Lucas Aschidamini Marcondes1
1Laboratory of Cognition and Memory Neurobiology, Brain Institute, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Av. Ipiranga, 6690 - 3rd floor, 90610-000, Porto Alegre, RS, Brazil.
Physiology & behavior
|October 8, 2023
概括
环境丰富 (EE) 增强了老鼠的长期记忆持久性. 这种效应取决于特定的大脑区域,包括底侧杏仁体,中间前额叶皮质和海马体,当训练后被禁用时.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 记忆研究 记忆研究
背景情况:
- 环境丰富 (EE) 有利于中枢神经系统功能,有助于治疗神经/精神疾病.
- 关于EE对健康动物的记忆持久性和涉及的大脑结构的影响的研究有限.
研究的目的:
- 调查EE对健康Wistar大鼠长期记忆持久性的影响.
- 确定特定的大脑区域,调解EE对记忆持久性的影响.
主要方法:
- 在背景恐惧调节 (CFC) 之前,大鼠被暴露在EE中,持续时间不同 (2-5周).
- 在CFC后的7,14和28天测试记忆持久性.
- 使用Muscimol在训练后的不同时间点进行了基底侧桃体 (BLA),中间前额叶皮层 (mPFC) 和CA1海马区域的非激活.
主要成果:
- 五周的EE促进了28天后测试的CFC记忆持久性;较短的EE持续时间或更早的测试没有影响.
- 在CFC训练后立即或12小时内非激活BLA,会影响EE对记忆持久性的影响.
- 在CFC训练后12小时内非激活CA1海马体或mPFC,但不立即,也会损害EE对记忆持久性的影响.
结论:
- 在健康的老鼠中,EE可以增强长期记忆的持久性,5周的暴露对长期回忆最有效.
- 底侧杏仁体,CA1海马体和中间前额叶皮质在调解EE对记忆持久性的有益影响方面发挥着关键作用.
- 这些发现有助于理解环境体验如何影响记忆的巩固和持久性.
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